Liver Comfort What is Hepten? Hepten is a natural product with a beneficial effect on damage to the liver and bile. What does Hepten contain? One liquid capsule (Solucaps) Hepten contains a high quality standardized extract of Sylibum marianum 125 mg, which is 100 mg of silymarin. Silymarin, on the other hand, is a mixture of isomeric flavonoid compounds (silybinin, silycristin and silydianin). The standardization process ensures the purity and efficacy of each Hepten capsule. Why is Hepten so special? Hepten differs from other preparations by the quality of the ingredients, the method of extraction and the pharmaceutical form. The pharmaceutical form Solucaps is a trademark. Since silymarin is slowly absorbed from the gastrointestinal tract after oral administration, the solucaps form allows rapid and complete absorption of the active ingredients. How does Hepten have a hepatoprotective effect? Silymarin neutralizes free radicals. This antioxidant effect causes the cessation of lipid peroxidation and prevention of further destruction of cellular structures. Silymarin reduces the production of superoxide radicals and nitric oxides by these cells. Silymarin increases the production of glutathione by the liver and intestines. Glutathione is used to detoxify liver cells (Valenzuela 1989). Toxic substances are converted into less toxic substances in the liver. Silymarin stimulates cell membrane function: inhibits toxin uptake and blocks toxin binding sites by altering the hepatocyte membrane (Hikino 1994, Leng-Pesclow 1996) How does Hepten accelerate liver cell regeneration? The regenerative effect of Hepten on liver cells (hepatocytes) is due to stimulation of the biosynthesis of structural and functional proteins. Silymarin stimulates a specific enzyme (RNA polymerase I) in the nuclei of hepatocytes, leading to an increase in the synthesis of ribosomal proteins and regeneration of the liver. This mechanism of action also plays a major role in amanita mushroom poisoning, as it blocks this enzyme in the nucleus of cells. Does Hepten have any other beneficial effects? Hepten has a beneficial effect on the composition of bile and has an effect on the gallbladder. It exhibits an anti-inflammatory effect by inhibiting inflammatory mediators (Leng-Pesclow 1996). It also has a protective effect on kidney cells (Sonnenbichler 1999). When to take Hepten? Hepten has a beneficial effect on liver and gallbladder damage in: - chronic inflammation of the liver (chronic hepatitis) - toxic and metabolic liver damage (alcohol and drugs, radiation damage, etc.) - liver steatosis and cirrhosis liver - long-term use of drugs that impair liver function - gallbladder dysfunction (dyskinesia of the bile ducts), cholelithiasis, chronic cholecystitis and others. - food poisoning, fungal poisoning with Amanita phalloida indigestion (dyspeptic complaints), decreased appetite, etc. How to use Hepten? We recommend 1-3 solucaps per day after a meal. The dose is individual. In severe liver damage, the dose of 1 solucaps is started three times a day and continues with a dose of 1 solucaps twice a day. Hepten can be combined with other hepatoprotective agents. Hepten Solucaps are taken whole with a little water without chewing. How to use Hepten in children? Take 1-2 Solucaps per day, depending on the age and weight of the child. The daily dose for children is 5 mg / kg of body weight, divided into 2-3 administrations. When to expect the effect? The effect does not occur immediately. According to scientific and clinical experience, improvement is observed after 8 to 12 weeks. How long should it continue to be taken? Use lasts 6 months. If necessary, the use can be repeated. Are there side effects? Hepten is a natural product and is practically harmless. Sometimes a small effect of weakness to the drug can occur. There is no contraindication and it is very well tolerated during prolonged use. Hepten® is a trademark of Borola. The product is manufactured in France in accordance with the highest requirements of Good Manufacturing Practice. To be stored in a dry place, inaccessible to children at a temperature below 25 ° C. Hepten is a food supplement.