Urimil is a dietary supplement that supports the normal function of the peripheral nervous system and provides relief from tingling and numbness in the hands and feet. Created to take care of the waist, back and limbs, each Urimil capsule contains an optimal combination of 6 essential nutrients that help regenerate damaged neurons. Useful information: Pain and stiffness in the waist, back or limbs can be the result of: injuries (fall, blow, dislocation, etc.) surgical operations inflammatory or infectious diseases (influenza, viral infections, etc.) other diseases (degenerative changes, narrowing of the spinal canal, spondylolisthesis, osteoporosis, blockage, projection pain in diseases of internal organs, cancer, diabetes, nutritional deficiencies, toxic agents and drugs) Some of the most common diseases of the peripheral nervous system are: sciatica lumbago discopathy cervical radiculitis intercostal neuralgia plexitis The peripheral nervous system (PNS) is an extension of the central nervous system (CNS), which consists of the brain and spinal cord. The main function of the peripheral nervous system is to connect the CNS to the limbs and organs of the body. Unlike the CNS, the PNS is not protected by bony tissue (skull and spine) like the brain and spinal cord and is vulnerable to damage. Nerve cells are the smallest structural units of the nervous system. Their number is about 100 billion, with each neuron connected to at least 10,000 others. Neurons in the nervous system vary in shape and size, but their structure is similar. A neuron has a body and extensions. One extension, called the axon, is longer than the others and is covered on the outside with a special myelin sheath, which plays the role of an insulator during the transmission of the nerve impulse. Through the axon, the cell sends information to other cells. When the myelin sheath (the "insulator") is damaged, the neuron cannot function normally and various symptoms occur, including pain. That pain is one of the manifestations of diseases of the peripheral nervous system which are very common. It turned out that every third person suffers from back pain (dorsalgia). Peripheral nerve regeneration In order for the body to activate its own regeneration mechanisms, certain nutrients are needed. Urimyl provides the body with the right combination of 6 essential nutrients, which help rebuild the myelin sheath and, hence, regenerate damaged neurons: Uridine monophosphate: Participates in the synthesis of nucleic acids; participates in the construction of cell membranes; builds dendrites, which support synaptic function; stimulates the formation of myelin (axon insulator), supports and accelerates neuromuscular regeneration and stops pain. Uridine is present in many nutritional products, but it is not bioavailable (uridine contained in food cannot be used), and this is due to the fact that it is broken down almost completely in the liver and in the gastrointestinal tract. Folic acid Folic acid, also called vitamin B9, is one of the most important vitamins for health: it participates in a number of enzymes; participates in the synthesis of DNA and RNA; participates in the synthesis of important amino acids; affects gene activity in nerve cells and helps regulate genes involved in regeneration; helps axonal regeneration and functional recovery after injuries. Vitamin B12 Vitamin B12, or cobalamin, is needed for the production of myelin. Numbness, tingling, and loss of sensation in the extremities are symptoms of peripheral neuropathy due to vitamin B12 deficiency. Statistical data show that between 5% and 20% of the adult population have a deficiency of vitamin B12, and up to 40% have a low level of vitamin B12 in the plasma. Vitamin B6 Vitamin B6 is important for amino acid, glucose and fat metabolism. In adults, vitamin B6-deficiency neuropathy begins with numbness or severe pain in the feet, which then travels upward to affect the legs and arms. Although vitamin B6 is present in many nutritious products, during the cooking process of the food, up to 70% of the vitamin is lost. On the other hand, humans are unable to synthesize vitamin B6, so intake from external sources is necessary. Vitamin B1 Thiamine (vitamin B1) is a water-soluble vitamin and is present in most plant and animal tissues. It is important for cellular respiration, for the production of neurotransmitters (glutamate and γ-aminobutyric acid) and for the maintenance of the myelin sheath. Thiamine deficiency leads to a neuropathy known as beriberi and is the first described vitamin deficiency syndrome in humans. As a result of a lack of vitamin B1 in the diet, within a few days to a few weeks, fatigue, irritability and muscle spasms may appear. The clinical picture of vitamin B1 deficiency begins with loss of sensitivity, severe pain, weakness in the muscles of the legs and feet. Vitamin B3 Vitamin B3, also known as niacin or nicotinic acid, is important for the metabolism of carbohydrates, fats and proteins, as well as for intercellular signal transduction and DNA repair in the cell. A lack of niacin in the diet can cause malaise, skin and oral lesions, anemia, headaches and fatigue. Purpose: Helps in the normal functioning of the peripheral nervous system. Composition of 1 capsule Uridine monophosphate 50 mg Vitamin B3 (nicotinamide) 10 mg NE Vitamin B6 (pyridoxine hydrochloride) 6 mg Vitamin B1 (thiamine hydrochloride) 4 mg Folic acid 400 µg Vitamin B12 (cyanocobalamin) 10 µg Other ingredients: stabilizer - maltodextrin, emulsifiers – magnesium stearate and microcrystalline cellulose. Recommended daily dose: 1 capsule per day. Duration of use: For optimal effect, it is recommended to use the product for 3-6 months. Contraindications: Do not use during pregnancy and breastfeeding. Do not use in case of hypersensitivity to any of the ingredients of the product. Warning: Do not exceed the recommended daily dose. The product is not a substitute for a varied diet. Keep out of reach of children. Do not use after the expiry date. Storage conditions: In a dry place, at a temperature below 25oC.